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Fatty acid elongation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(3S)-3-hydroxytetradecanoyl-CoA <=> 2-tetradecenoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase


(S)-3-hydroxydecanoyl-CoA <=> trans-2-decenoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase


acetyl-CoA + myristoyl-CoA <=> CoA + 3-ketohexadecanoyl-CoA 2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase


L-3-hydroxydodecanoyl-CoA + NAD+ <=> 3-oxododecanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


hexanoyl-CoA + acetyl-CoA <=> 3-oxooctanoyl-CoA + CoA 2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase


(3S)-3-hydroxyacyl-CoA <=> trans-2-enoyl-CoA + H2O 4.2.1.119 enoyl-CoA hydratase 2
4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase




L-3-hydroxydodecanoyl-CoA <=> trans-2-dodecenoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase


acyl-CoA + NADP+ <=> trans-2-enoyl-CoA + NADPH + H+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.44 trans-2-enoyl-CoA reductase (NAD+)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)



butyryl-CoA + acetyl-CoA <=> 3-oxohexanoyl-CoA + CoA 2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase



decanoyl-CoA + acetyl-CoA <=> 3-oxododecanoyl-CoA + CoA 2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase


acyl-CoA + NADP+ <=> trans-2-enoyl-CoA + NADPH + H+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.44 trans-2-enoyl-CoA reductase (NAD+)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)



a_very-long-chain_(3R)-3-hydroxyacyl-CoA + NADP+ <=> a_very-long-chain_3-oxoacyl-CoA + NADPH + H+ 1.1.1.330 very-long-chain 3-oxoacyl-CoA reductase

(3S)-3-hydroxyacyl-CoA + NAD+ <=> 3-oxoacyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
1.1.1.36 acetoacetyl-CoA reductase
1.1.1.M19




(S)-3-hydroxyoctanoyl-CoA <=> 2-octenoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase


(3S)-hydroxyhexadecanoyl-CoA <=> trans-2-hexadecenoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase


trans-2-decenoyl-CoA + NADPH <=> decanoyl-CoA + NADP+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)


octanoyl-CoA + acetyl-CoA <=> 3-oxodecanoyl-CoA + CoA 2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase


(S)-3-hydroxyoctanoyl-CoA + NAD+ <=> 3-oxooctanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


trans-2-dodecenoyl-CoA + NADPH <=> lauroyl-CoA + NADP+ 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)




lauroyl-CoA + acetyl-CoA <=> 3-oxotetradecanoyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase

2-tetradecenoyl-CoA + NADPH <=> myristoyl-CoA + NADP+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)


palmitoyl-CoA + NADP+ <=> trans-2-hexadecenoyl-CoA + NADPH + H+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)


behenoyl-CoA + NADP+ <=> trans-docos-2-enoyl-CoA + NADPH + H+ 1.3.1.93 very-long-chain enoyl-CoA reductase

acyl-CoA + acetyl-CoA <=> 3-oxoacyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase

(S)-3-hydroxydecanoyl-CoA + NAD+ <=> 3-oxodecanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


(3S)-3-hydroxytetradecanoyl-CoA + NAD+ <=> 3-oxotetradecanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


palmitoyl-CoA + H2O <=> H+ + palmitate + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
3.1.1.1 carboxylesterase
3.1.1.23 acylglycerol lipase
3.1.1.5 lysophospholipase
3.1.2
3.1.2.1 acetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.22 palmitoyl[protein] hydrolase
3.1.2.25 phenylacetyl-CoA hydrolase










behenoyl-CoA + malonyl-CoA <=> a_very-long-chain_3-oxoacyl-CoA + CO2 + CoA 2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase

trans-2-hexenoyl-CoA + NADPH <=> hexanoyl-CoA + NADP+ 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.44 trans-2-enoyl-CoA reductase (NAD+)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)




2-octenoyl-CoA + NADPH <=> octanoyl-CoA + NADP+ 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)



(S)-3-hydroxyhexanoyl-CoA + NAD+ <=> 3-oxohexanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


a_very-long-chain_(3R)-3-hydroxyacyl-CoA <=> very-long-chain_(2E)-2-enoyl-CoA + H2O 4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

(S)-3-hydroxyhexanoyl-CoA <=> trans-2-hexenoyl-CoA + H2O 4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase



(3S)-hydroxyhexadecanoyl-CoA + NAD+ <=> 3-ketohexadecanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


palmitoyl-CoA + H2O <=> H+ + palmitate + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
3.1.1.1 carboxylesterase
3.1.1.23 acylglycerol lipase
3.1.1.5 lysophospholipase
3.1.2
3.1.2.1 acetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.22 palmitoyl[protein] hydrolase
3.1.2.25 phenylacetyl-CoA hydrolase










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